Police were called Friday night just after 7:30 in Plains Township to the Red Roof Inn along Route 315.
They found 27-year-old Leslie Smith inside car that had just been in a crash at the entrance to the motel.
Smith was found with multiple gunshot wounds in the car and died at the scene.
Smith's killer remains on the run.
Anyone with information is urged to call the State Police Wyoming Barracks at 570-697-2000.