The lab was discovered at the home along Chestnut Street Thursday afternoon when police were trying to find a man on probation.
That's when they discovered all of the ingredients used in the manufacturing of meth.
The man on probation Michael Olah along with Samuel Conrad, Heather Wynings and a juvenile girl were all taken into custody.
John Soprano, Regional Director of Attorney General's Office told Eyewitness News
"This is the third one (Meth Lab) we've done in Berwick since January. I believe it's 3 and within the latter part of last year I think we are up to 25 now."
Neighbors are hoping that other drug makers see this latest bust and get the message that enough is enough.
Crews were on the scene for several hours and officials say this bust was one of the more dangerous that they've seen because of the hazardous materials being used.